邓红文

发布日期:2015-01-15     点击数:553    来源:湖南师范大学科技处

邓红文, “长江学者奖励计划”特聘教授,博导。1966年出生,1990年毕业于北京大学生物系,同年留学美国,1995年在美国Oregon大学生物系和数学系获得遗传学博士学位和统计学硕士学位,师从于国际著名的统计遗传学权威Micheal Lynch教授,又在美国休斯顿Texas大学人类遗传中心从事博士后研究工作一年半,1997年起在Creighton大学担任助理教授,主持一个有八个博士的遗传学实验室,2001年3月成为Creighton大学有史以来最年轻的副教授(Tenured Associate Professor of Medicine and BioMedical Sciences)。2000年被聘为湖南师范大学特聘教授。2001年被教育部批准为“长江学者奖励计划”特聘教授,并获得国家杰出青年科学基金课题。在美留学期间他以复杂性状与疾病为研究对象,以遗传与突变为研究的核心问题,从事了进化生物学、分子进化遗传学、群体及数量遗传学、生态遗传学、骨医学、骨质分子遗传学、计算和统计遗传学等跨学科和交叉学科的研究,并取得了杰出成就。他的主要科研成就有:1)发展了“邓-林奇”(Deng-Lynch)法来测定基因突变的突变率、突变对机体的危害及其遗传效应。有关这项工作的一系列文章发表在美国遗传学报(Genetics)上。主要因为这项工作,他于1997年获得美国自然科学家协会的优秀青年科学奖;2)第一次发现并证实维生素-D的受体基因和雌性激素的受体在一定程度上决定人类骨质密度的自然变化及药理调控。这项工作发表在Human Genetics及国际骨质研究学刊(Osteoporosis International)上。他为此于1999年4月获美国骨学研究会第一次有命名的(John addad)优秀青年科学家奖;3)第一次发现并证实人类的手腕骨折有其重要的遗传原理及机制。这项工作为寻找人类骨折基因打下了坚实的基础。邓红文博士在Nature、Genetics、Human Genetics、J Bone and Mineral Res、 Evolution、Molecular Biology and Evolution、 Heredity、Genetical Research、Genetica和American J Human Genetics等国际权威刊物上共发表了50余篇论文。其中第一作者和独著或联系作者的论文40余篇,全部文章被SCI收录,论文总引用达200余次。    邓红文博士承担和主持过国家级重大课题7项,获得国际和美国各种杰出青年科学家奖9项,7次应邀在国际重要学术会议上作专题报告,为13个国际一流杂志和美国NSF等基金组织担任评审。目前邓红文博士在美国Creighton大学医学院主持一个遗传学研究室,在研课题6项,经费323.35万美元;在湖南师范大学生命科学学院主持一个分子与统计遗传学研究室,主要开展人类复杂多基因遗传疾病(如骨质疏松、高血压、心脏病、癌症等)基因的分子遗传分析与鉴定。承担的课题有:国家杰出青年科学基金课题1项、国家自然科学基金面上项目1项、湖南省特聘教授基金课题1项、教育部留学回国人员启动基金课题1项,课题经费385万元人民币。该研究室已初具规模,与国内外同行已建立起了广泛的联系,各项研究工作已全面展开并取得了良好的进展。  
 
附主要代表作:

1. Deng,H.-W.,Population Admixture May Appear to mask, change or Rererse Genetic  Effects of Genes Underlying Complex Traits.  Genetics,2001,159:1319-1323。

2..Tan,Y.,D.and H.-W.Deng, An Amplified Fragment length Polxmorphism Nap of the Silkworm. Genetics 2001,157:1277-1284。

3.Deng,H.-W.,J. Li,The effect of polygenes on transmission disquilibrium test of a QTL in nuclear families  with multiple children. Genet Epodemiology.2001,21,243-265.

4. Deng,H.-W.,Biased tests of association:comparison of allele frequencies when departing from Hardy-Weinberg proportions2000 Am.Jepidemiology,151:335-357.                               

5. Deng,H.-W.,Determination of BND at hip and spine by genetic and life-style factors. Gemetics  Epidemiology,2000:19:160-177.             
6. Deng,H.-W.,Characterizing deleterious genomic mutations in partial seltfing/outcrossing  populations and in nonequilium Popuations.2000 Genetics 154:1839-1906.(*Deng is the corresponding author). 
7. Deng,H.-W.,Pooduct difference of multiplex and singleplex PCR and its practical for human genctic oTechniques.2000,29:298
-308     
8. Deng,H.-W.,QTL fine mapping in extreme samples of finite populations for complex traits  with familial correlation due to
polygenes  Am.J Himan Genet”(2000,67:259-261)                                    
9. Deng,H.-W Association of Estrogen Receptor-alpha(ER)Genotypes with Body Mass  Index in Normal Healthy Postmenopausal
Caucsisn Women.  J Clincical Endocrinology and Mrtabolism.2000,85:2748-2751.             
10. Deng, H .-W., J. Li , and J.- Li. Recovery of mutations of different size from a   population sample of DNA sequences
under variable mutation rates across sites.Moleclar Biology and Evolution,1999,618:1098-1104.
11. H. -W., Deng,V.Haynatzka, Spitze,K.and G.Haynatzki.On the determination of  genetic  covariances and prediction of
evolutionary trajectories based on genetic  correlations matrix.  Evolution. 1999,53(5):1592-1599.
12. Deng,HW,J.Li,J.L.Li,M.Johnson,M.Davies and RR Recker.  Change  of  bone  mass in postmenopausal Caucasian women with and
without hormone replacement  therapy is associated with Vitamin D receptor and estrogen receptor genotypes. Human Genetics.1998,103:576-585.
13. Li , J.- L .,  J. Li and  H .- W. Deng . The  effects of  overdominance  on characterizing deleterious genomic mutations
in large natural populations.  Genetics. 1999,151:895-913.
14. Deng,H.W. Estimation of deleterious-mutation rate and efficts in outcrossing   populations.  Genetics. 1998,150: 945-956.
15. Deng,H.-W.,J.Li, and J.-L.Li  On the  experimental designs and data  analyses of mutation accumulation
experiments.Genetical Research. 1999,73:147-194.
16. Deng,H.-W,J.L.Li,J.Li,M.K.Davies,and R.R. Recker. Heterogeneity  of  bone  mass density  across skeletal sites and its
clnical implications. J Clinical Densitometry.1998, 1:339-353.
17. Deng, H.-W. Estimating coefficient of (over)dominance from inbreeding data and discriminating dominance and overdominance
hypothesis for heterosis. Genetics .1998,148:1333-1340.
18. Deng, H.- W. and Y.- X. Fu. On the three different  approaches to  estimating  deleterious  genomic mutation parameters. 
Genetical Research .1998,71 (3): 223-236.
19.Deng ,H.-W.,D.B. Kimel, T. Conway, K. M.Davies, R. R. Recker High narrow-sense  heritability for peak bone mass in humans.
J Bone Miner Res.1997, 12:S563.
20.Deng, H.- W. and M. Lynch.  Inbreeding depression and the inferred genomic  mutation parameters in Daphnia species.
Genetics, 1997,147:147-155.
21.Deng, H. - W.  Increase of  dvelopmental  instability  upon inbreeding in Daphnia. Heredity,1997,78: 182-189.
22 .Deng, H-W.and Y.-X. Fu. The effects of variable mutation rate  across  sites on the phylogenetic  estimation of
population size or  mutation rate of  DNA sequences. Genetics, 1996,144: 1271-1281.
23.Deng, H.-W. and M. Lynch. Estimation of  deleterious- mutation  parameters  in nature populations. Genetics, 1996,
144:349-360.
24.Deng,H.- W. and M.Lynch.  Change of genetic architecture in response to sex.  Genetics, 1996,143:203-212.
25.Deng, H. - W. Environmental and genetic  control of sexual  reproduction in  Daphnia.  Heredity,1996,76:449-458.
26.Deng,H.-W.Sexual reproduction in Daphnia: its control and genetieconsequences..Ph.D.Thesis. University of Oregon(Advisor-
Dr.Michael Lynch). 1995
27.Deng, H.-W. and T. Kibota,  The importance of  environmental variance and   covariance  structure in predicting
evolutionary response.  Evolution.1995, 49: 572-574.
28.Butcher, D. and H.-W.Deng.  Hypothetical“Sister Killer”.  Nature. 1994, 369: 26.
29.Lynch,M. and H.-W. Deng.  Genetic slippage in response to sex.American Naturalist. 1994, 144:242-261.